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Clinical Trial
. 2011;50(19):2163-8.
doi: 10.2169/internalmedicine.50.5456. Epub 2011 Oct 1.

Pramipexole reduces the prevalence of fatigue in patients with Parkinson's disease

Akihiko Morita  1 , Yasuyuki Okuma, Satoshi Kamei, Fumihito Yoshii, Toshimasa Yamamoto, Shiori Hashimoto, Hiroya Utsumi, Taku Hatano, Nobutaka Hattori, Miyuki Matsumura, Kazushi Takahashi, Shigeru Nogawa, Yuka Watanabe, Tomoyuki Miyamoto, Masayuki Miyamoto, Koichi Hirata
Affiliations
Free article
Clinical Trial

Pramipexole reduces the prevalence of fatigue in patients with Parkinson's disease

Akihiko Morita et al. Intern Med. 2011.
Free article

Abstract

Objective: The aim of this multicenter cross-sectional study was to assess the relation between fatigue in a large number of Japanese patients with Parkinson's disease (PD) and drugs taken to treat PD.

Method: We used the 16-item Parkinson Fatigue Scale (PFS-16), which was designed to assess fatigue exclusively associated with PD. Multiple logistic regression analyses were used to assess the relation between antiparkinson drugs and fatigue in PD.

Results: A total of 350 non-demented PD patients were enrolled. Fatigue (PFS score of ≥4) was revealed in 319 patients (91%). Pramipexole was administered to 24% of PD patients. Multiple logistic regression analysis revealed that the administration of Pramipexole was significantly related to low rates of fatigue in PD patients with Hoehn and Yahr stage <3 (p=0.011, odds ratio=5.23, 95% confidence interval; 1.47-18.63).

Conclusion: The reduced fatigue in PD patients was observed in taking Pramipexole.

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