Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Oct 3;9(12):889-93.
doi: 10.1038/nrmicro2668.

The development of vaccines: how the past led to the future

Stanley A Plotkin  1 , Susan L Plotkin
Affiliations
Review

The development of vaccines: how the past led to the future

Stanley A Plotkin et al. Nat Rev Microbiol. .

Abstract

The history of vaccine development has seen many accomplishments, but there are still many diseases that are difficult to target, and new technologies are being brought to bear on them. Past successes have been largely due to elicitation of protective antibodies based on predictions made from the study of animal models, natural infections and seroepidemiology. Those predictions have often been correct, as indicated by the decline of many infections for which vaccines have been made over the past 200 years.

PubMed Disclaimer

References

    1. J Exp Med. 1969 Jun 1;129(6):1349-65 - PubMed
    1. JAMA. 1971 Jan 25;215(4):613-9 - PubMed
    1. Am J Hyg. 1954 Jul;60(1):52-62 - PubMed
    1. Dev Biol Stand. 1978;40:3-9 - PubMed
    1. Vaccine. 2000 Dec 8;19(9-10):1232-8 - PubMed

LinkOut - more resources