Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Jan;28(1):49-52.
doi: 10.1016/j.eurpsy.2011.07.005. Epub 2011 Oct 2.

Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

G-D Batty  1 , Q Li, R Huxley, S Zoungas, B-A Taylor, B Neal, B de Galan, M Woodward, S-B Harrap, S Colagiuri, A Patel, J Chalmers; VANCE Collaborative group
Affiliations

Oral disease in relation to future risk of dementia and cognitive decline: prospective cohort study based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (ADVANCE) trial

G-D Batty et al. Eur Psychiatry. 2013 Jan.

Abstract

Objective: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes.

Methods: A total of 11,140 men and women aged 55-88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up.

Results: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes.

Conclusions: Tooth loss was associated with an increased risk of both dementia and cognitive decline.

PubMed Disclaimer

References

    1. Jones JA, Lavallee N, Alman J, Sinclair C, Garcia RI. Caries incidence in patients with dementia. Gerodontology. 1993 Dec;10(2):76–82. - PubMed
    1. Ship JA, Puckett SA. Longitudinal study on oral health in subjects with Alzheimer’s disease. J Am Geriatr Soc. 1994 Jan;42(1):57–63. - PubMed
    1. Chauncey HH, Muench ME, Kapur KK, Wayler AH. The effect of the loss of teeth on diet and nutrition. Int Dent J. 1984 Jun;34(2):98–104. - PubMed
    1. Luchsinger JA, Mayeux R. Dietary factors and Alzheimer’s disease. Lancet Neurol. 2004 Oct;3(10):579–87. - PubMed
    1. Stewart R, Masaki K, Xue QL, et al. A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study. Arch Neurol. 2005 Jan;62(1):55–60. - PubMed

Publication types