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Comparative Study
. 2012 Jan;67(1):154-8.
doi: 10.1093/jac/dkr399. Epub 2011 Sep 29.

Automated quantitative drug susceptibility testing of non-tuberculous mycobacteria using MGIT 960/EpiCenter TB eXiST

Katja Lucke  1 , Michael Hombach, Ute Friedel, Claudia Ritter, Erik C Böttger
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Free article
Comparative Study

Automated quantitative drug susceptibility testing of non-tuberculous mycobacteria using MGIT 960/EpiCenter TB eXiST

Katja Lucke et al. J Antimicrob Chemother. 2012 Jan.
Free article

Abstract

Objectives: To assess the predictive value of in vitro drug susceptibility testing (DST) in slow-growing non-tuberculous mycobacteria (NTM), knowledge on quantitative levels of drug susceptibility should be available. The aim of this study was to investigate the suitability of the MGIT 960/TB eXiST system for quantitative DST of NTM.

Methods: We have assessed quantitative levels of drug susceptibility for clinical isolates of Mycobacterium avium, Mycobacterium intracellulare and Mycobacterium kansasii by comparing radiometric Bactec 460TB-based DST with non-radiometric DST using MGIT 960/TB eXiST.

Results: MGIT 960/TB eXiST gives results comparable to those of Bactec 460TB.

Conclusions: The MGIT 960/TB eXiST appears suitable for quantitative DST of NTM.

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