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Case Reports
. 2012 Sep-Oct;29(5):662-3.
doi: 10.1111/j.1525-1470.2011.01510.x. Epub 2011 Oct 4.

Safe and successful treatment of acne vulgaris with isotretinoin in a patient with chronic granulomatous disease

Ricardo M Alonso-de-Celada  1 , Raúl de-Lucas Laguna
Affiliations
Case Reports

Safe and successful treatment of acne vulgaris with isotretinoin in a patient with chronic granulomatous disease

Ricardo M Alonso-de-Celada et al. Pediatr Dermatol. 2012 Sep-Oct.

Abstract

Isotretinoin for acne vulgaris in the setting of chronic granulomatous disease (CGD) is a controversial therapeutic option. In this inherited immunodeficiency, inefficient tissue responses to bacteria and fungi lead to chronic and recurrent infections. Isotretinoin is known to be associated with several mucocutaneous side effects that could worsen the immune response in individuals with CGD. We report the fourth published case of acne vulgaris treated with isotretinoin in an individual with CGD, with a safe and successful outcome.

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