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. 2011 Nov 4;13(21):5770-3.
doi: 10.1021/ol202334s. Epub 2011 Oct 3.

A facile synthesis of substituted 2-alkylquinolines through [3+3] annulation between 3-ethoxycyclobutanones and aromatic amines at room temperature

Gang Shan  1 , Xiuyun Sun, Qian Xia, Yu Rao
Affiliations

A facile synthesis of substituted 2-alkylquinolines through [3+3] annulation between 3-ethoxycyclobutanones and aromatic amines at room temperature

Gang Shan et al. Org Lett. .

Abstract

An efficient single-step approach toward the synthesis of 2-alkylquinolines is described. Through a Lewis acid mediated [3+3] annulation reaction between 3-ethoxycyclobutanones and aromatic amines, a variety of multisubstituted 2-alkylquinoline derivatives were prepared regioselectively at room temperature.

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