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Comment
. 2011 Oct 11;108(41):16867-8.
doi: 10.1073/pnas.1113321108. Epub 2011 Oct 3.

Chromatin plasticity and the pathogenesis of Huntington disease

Affiliations
Comment

Chromatin plasticity and the pathogenesis of Huntington disease

Michelle E Ehrlich et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
X-ray crystal structure of a nucleosome assembled with macroH2A (Protein Data Bank 1U35; α-satellite DNA + Mus musculus H3, H4, H2B + Homo sapiens macroH2A11). [Reprinted from ref. with the permission of the authors.]
Fig. 2.
Fig. 2.
Schematic diagram contrasting the molecular changes in macroH2A occupancy that occur at genes activated or repressed by macroH2A. [Reprinted from ref. with the permission of the authors.]

Comment on

References

    1. Hu Y, et al. Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse. Proc Natl Acad Sci USA. 2011;108:17141–17146. - PMC - PubMed
    1. Mueller SG, et al. Ways toward an early diagnosis in Alzheimer's disease: The Alzheimer's Disease Neuroimaging Initiative (ADNI) Alzheimers Dement. 2005;1:55–66. - PMC - PubMed
    1. Aizenstein HJ, et al. Frequent amyloid deposition without significant cognitive impairment among the elderly. Arch Neurol. 2008;65:1509–1517. - PMC - PubMed
    1. Gandy S. Perspective: Prevention is better than cure. Nature. 2011;475:S15. - PMC - PubMed
    1. Robinson S, Pool R, Giffin R. Emerging Safety Science. Forum on Drug Discovery, Development, and Translation. Washington, DC: National Academies Press; 2008.

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