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. 2010 Nov;72(6):689-96.
doi: 10.4103/0250-474X.84576.

Polymers for colon targeted drug delivery

H Rajpurohit  1 , P Sharma, S Sharma, A Bhandari
Affiliations

Polymers for colon targeted drug delivery

H Rajpurohit et al. Indian J Pharm Sci. 2010 Nov.

Abstract

The colon targeted drug delivery has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery systems have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. Targeting of drugs to the colon via oral administration protect the drug from degradation or release in the stomach and small intestine. It also ensures abrupt or controlled release of the drug in the proximal colon. Various drug delivery systems have been designed that deliver the drug quantitatively to the colon and then trigger the release of drug. This review will cover different types of polymers which can be used in formulation of colon targeted drug delivery systems.

Keywords: Biodegradable polymers; colon targeted delivery; controlled delivery; polysaccharides.

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Figures

Fig. 1
Fig. 1
Structure of Guar Gum
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Fig. 2
Structure of Pectin
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Structure of chondroitin sulfate
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Structure of dextran
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Structure of chitosan
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Structure of α-cyclodextrin
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Structure of inulin
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Fig. 8
Structure of amylose
See this image and copyright information in PMC

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References

    1. Wilson CG, Mukherji G, Sha HK. Modified-release Drug Delivery Technology. In: Rathbone MJ, Had graft J, Roberts MS, Lane ME, editors. Biopolymers and Colonic Delivery. 2nd ed. Vol. 1. New York: Informa Healthcare; 2008. pp. 295–309.
    1. Jose S, Dhanya K, Cinu TA, Litty J, Chacko AJ. Colon Targeted drug delivery: Different approaches. J Young Pharm. 2009;1:13–9.
    1. Kumar RS, Kumar M, Ganesh GN, Jawahar N, Nagasamyvenkatesh D, Senthil V, et al. Formulation and evaluation of pectin-hydroxypropyl methylcellulose coated curcumin pellets for colon delivery. Asian J Pharm. 2009;3:138–42.
    1. Vyas SP, Khar RK. Systems for colon specific delivery. In: Vyas Sp, Khar RK., editors. Controlled drug delivery: Concept and advantages. 1st ed. Delhi: Vallabh Prakashan; 2002. pp. 218–56.
    1. Jain S, Jain NK. Polymers in Pharmaceutical Sciences. In: Jain NK, editor. Pharmaceutical Product Development. 1st ed. New Delhi: CBS Publisher and Distributor; 2006. pp. 218–26.

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