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. 2011 Nov 4;17(45):12591-5.
doi: 10.1002/chem.201102475. Epub 2011 Oct 4.

Rhodium-catalyzed annulation of N-benzoylsulfonamide with isocyanide through C-H activation

Chen Zhu  1 , Weiqing Xie, John R Falck
Affiliations

Rhodium-catalyzed annulation of N-benzoylsulfonamide with isocyanide through C-H activation

Chen Zhu et al. Chemistry. .

Abstract

Isocyanide insertion: the first rhodium-catalyzed annulation of N-benzoylsulfonamide incorporating with isocyanide via C-H activation is described. The transformation is broadly compatible with N-benzoylsulfonamides bearing various electron-properties as well as isocyanides. From practical point of view, this methodology provides the most straightforward approach to a series of 3-(imino)isoindolinones.

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Figures

Figure 1
Figure 1
Plausible Mechanism
Figure 2
Figure 2
Steric Influence of Isocyanide on Isomer Ratio
Scheme 1
Scheme 1
Annulation with C1 Source via C-H Activation
See this image and copyright information in PMC

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