Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2011 Oct;96(10):1402-5.
doi: 10.3324/haematol.2011.052175.

Chronic lymphocytic leukemia--genomics lead the way

Daniel Mertens, Lars Bullinger, Stephan Stilgenbauer
Editorial

Chronic lymphocytic leukemia--genomics lead the way

Daniel Mertens et al. Haematologica. 2011 Oct.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Putative model for the mechanism of leukemogenesis of chronic lymphocytic leukemia. (A) Hematopoietic stem cells sorted from a CLL patient’s bone marrow produce a CLL-like disease when transplanted into immunosuppressed mice. It has, therefore, been postulated that hematopoietic stem cells from CLL patients already harbor (pre)leukemia-initiating events. (B) The biased usage of specific immunglobulin heavy chain variable gene segments (IGHV) in CLL cells suggests antigenic stimulation as a pro-survival and/or pro-proliferative selective drive. While only shown at a single stage in this figure, antigenic stimulation of CLL cells with non-mutated IGHV is likely to occur at all stages of disease development. (C) This results in oligoclonal expansion of pre-malignant cells. (D) Secondary (epi)genomic and/or cytogenetic lesions result in malignant transformation and (E) massive accumulation of CLL cells with further selection e.g. of clones with loss of function of TP53 (17p) and potentially other genes during the selective pressure of chemotherapy.
See this image and copyright information in PMC

Comment on

References

    1. Zenz T, Mertens D, Kuppers R, Dohner H, Stilgenbauer S. From pathogenesis to treatment of chronic lymphocytic leukaemia. Nat Rev Cancer. 2010;10(1):37–50. - PubMed
    1. Ghia P, Chiorazzi N, Stamatopoulos K. Microenvironmental influences in chronic lymphocytic leukaemia: the role of antigen stimulation. J Intern Med. 2008;264(6):549–62. - PubMed
    1. Kikushige Y, Ishikawa F, Miyamoto T, Shima T, Urata S, Yoshimoto G, et al. Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia. Cancer Cell. 2011;20(2):246–59. - PubMed
    1. Dohner H, Stilgenbauer S, Benner A, Leupolt E, Krober A, Bullinger L, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med. 2000;343(26):1910–6. - PubMed
    1. Stilgenbauer S, Sander S, Bullinger L, Benner A, Leupolt E, Winkler D, et al. Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival. Haematologica. 2007;92(9):1242–5. - PubMed