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Editorial
. 2011 Oct;96(10):1402-5.
doi: 10.3324/haematol.2011.052175.

Chronic lymphocytic leukemia--genomics lead the way

Daniel Mertens, Lars Bullinger, Stephan Stilgenbauer
Editorial

Chronic lymphocytic leukemia--genomics lead the way

Daniel Mertens et al. Haematologica. 2011 Oct.
No abstract available

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Figures

Figure 1.
Figure 1.
Putative model for the mechanism of leukemogenesis of chronic lymphocytic leukemia. (A) Hematopoietic stem cells sorted from a CLL patient’s bone marrow produce a CLL-like disease when transplanted into immunosuppressed mice. It has, therefore, been postulated that hematopoietic stem cells from CLL patients already harbor (pre)leukemia-initiating events. (B) The biased usage of specific immunglobulin heavy chain variable gene segments (IGHV) in CLL cells suggests antigenic stimulation as a pro-survival and/or pro-proliferative selective drive. While only shown at a single stage in this figure, antigenic stimulation of CLL cells with non-mutated IGHV is likely to occur at all stages of disease development. (C) This results in oligoclonal expansion of pre-malignant cells. (D) Secondary (epi)genomic and/or cytogenetic lesions result in malignant transformation and (E) massive accumulation of CLL cells with further selection e.g. of clones with loss of function of TP53 (17p) and potentially other genes during the selective pressure of chemotherapy.
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