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. 2011 Nov 4;13(21):5792-5.
doi: 10.1021/ol202367d. Epub 2011 Oct 5.

Copper(I) catalyzed regioselective asymmetric alkoxyamination of aryl enamide derivatives

Masafumi Nakanishi  1 , Corinne Minard, Pascal Retailleau, Kevin Cariou, Robert H Dodd
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Free article

Copper(I) catalyzed regioselective asymmetric alkoxyamination of aryl enamide derivatives

Masafumi Nakanishi et al. Org Lett. .
Free article

Abstract

The copper(I) catalyzed reaction of an enamide with an iminoiodane, in the presence of an alcohol, triggers the direct alkoxyamination of the double bond. This transformation represents a straightforward access to α-amino aminals in a completely regio- and diastereoselective manner. Use of a chiral Box ligand allows this reaction to be carried out in an enantioselective fashion.

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