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. 2012 Jan;36(1):29-31.
doi: 10.1016/j.leukres.2011.09.009. Epub 2011 Oct 4.

Estimation of the prevalence of Fanconi anemia among patients with de novo acute myelogenous leukemia who have poor recovery from chemotherapy

Andrzej Rochowski  1 , Philip S Rosenberg, Todd A Alonzo, Robert B Gerbing, Beverly J Lange, Blanche P Alter
Affiliations

Estimation of the prevalence of Fanconi anemia among patients with de novo acute myelogenous leukemia who have poor recovery from chemotherapy

Andrzej Rochowski et al. Leuk Res. 2012 Jan.

Abstract

We speculated that some individuals with de novo acute myelogenous leukemia (AML) may have undiagnosed Fanconi Anemia (FA). Data from patients enrolled on AML protocol CCG-2961, published FA cohort studies, SEER, and Bayes rule were used to estimate the probability of FA among all newly diagnosed AML cases, and among those who had no or delayed recovery of the absolute neutrophil count following initial chemotherapy. We determined that the probability of undiagnosed FA in patients in a treatment trial for newly diagnosed patients was around 0.18%, and around 0.83% in the subset who had poor marrow recovery. We suggest that FA or other inherited bone marrow failure syndromes be considered prior to treatment, or certainly among those with poor recovery.

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Figures

Fig. 1
Fig. 1
Time to recovery of absolute neutrophil count (ANC) >1000/μL in 892 de novo AML patients on CCG-2961. Raw data are shown by the bars. Note the change to the right Y-axis for the patients who failed to recover their ANC. There were 28 patients who recovered after 60 days, and 165 who never recovered.
See this image and copyright information in PMC

References

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