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. 2012 Jan;70(1):205-9.
doi: 10.1016/j.apradiso.2011.09.005. Epub 2011 Sep 17.

Automated synthesis of [18F]gefitinib on a modular system

Tilman Läppchen  1 , Maria L H Vlaming, Erica Custers, Johan Lub, Charles F Sio, Jeroen DeGroot, Oliver C Steinbach
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Automated synthesis of [18F]gefitinib on a modular system

Tilman Läppchen et al. Appl Radiat Isot. 2012 Jan.

Abstract

In recent years, [(18)F]gefitinib PET has successfully been employed for a number of applications ranging from oncology to in vivo studies of drug transporter proteins. We here report a reliable, automated procedure for routine synthesis of this radiotracer on an Eckert and Ziegler modular system. The 3-step radiosynthesis followed by preparative HPLC-purification provided [(18)F]gefitinib in 17.2±3.3% (n=22) overall decay-corrected radiochemical yield with radiochemical purity >99% in a total synthesis time of about 2.5h.

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