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. 2011 Nov;90(5):737-42.
doi: 10.1038/clpt.2011.195. Epub 2011 Oct 5.

Developing a valid patient-reported outcome measure

N E Rothrock  1 , K A Kaiser, D Cella
Affiliations

Developing a valid patient-reported outcome measure

N E Rothrock et al. Clin Pharmacol Ther. 2011 Nov.

Abstract

Many aspects of patients’ experiences with illness, medication, and health care are best captured from patient-reported outcomes (PROs). In this article, we describe the process for constructing quality PRO instruments, from conceptual model development through instrument validation. We also discuss PROs as clinical trial end points and the potential of PRO data for aiding clinicians and patients in choosing from among multiple therapeutic options. Finally, we provide an overview of some existing PRO instruments.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors declared no conflict of interest.

Figures

Figure 1
Figure 1
Patient-reported outcome (PRO) instrument development process.
See this image and copyright information in PMC

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