Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Jul 11;18(13):3841-5.
doi: 10.1093/nar/18.13.3841.

MutY, an adenine glycosylase active on G-A mispairs, has homology to endonuclease III

M L Michaels  1 , L Pham, Y Nghiem, C Cruz, J H Miller
Affiliations
Free PMC article

MutY, an adenine glycosylase active on G-A mispairs, has homology to endonuclease III

M L Michaels et al. Nucleic Acids Res. .
Free PMC article

Abstract

The mutY gene of Escherichia coli, which codes for an adenine glycosylase that excises the adenine of a G-A mispair, has been cloned and sequenced. The mutY gene codes for a protein of 350 amino acids (Mr = 39,123) and the clone genetically complements the mutY strain. The protein shows significant sequence homology to E. coli endonuclease III, an enzyme that has previously been shown to have glycosylase activity on damaged base pairs. Sequence analysis suggests that, like endonuclease III, MutY is an iron-sulfur protein with a [4Fe-4S]2+ cluster.

PubMed Disclaimer

References

    1. Nucleic Acids Res. 1988 Feb 11;16(3):1220 - PubMed
    1. Proc Natl Acad Sci U S A. 1987 Dec;84(24):8854-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1988 Apr;85(8):2444-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1988 Apr;85(8):2709-13 - PubMed
    1. Genetics. 1988 Apr;118(4):593-600 - PubMed

Publication types

Associated data