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. 2011 Oct;85(4):697-702.
doi: 10.4269/ajtmh.2011.10-0692.

Aggregate evaluable organ dysfunction predicts in-hospital mortality from sepsis in Uganda

Richard Ssekitoleko  1 , Relana Pinkerton, Rose Muhindo, Sanjay Bhagani, Christopher C Moore
Affiliations

Aggregate evaluable organ dysfunction predicts in-hospital mortality from sepsis in Uganda

Richard Ssekitoleko et al. Am J Trop Med Hyg. 2011 Oct.

Abstract

We evaluated the association between severity of sepsis and in-hospital mortality in 150 patients with non-surgical sepsis at a regional referral hospital in Uganda. In-hospital mortality occurred in 5 of 52 (9.6%) patients with sepsis, 24 of 71 (33.8%) patients with severe sepsis, and 16 of 27 (59.3%) patients with septic shock. In the multivariate analysis, the identification of severe sepsis (adjusted hazard ratio [AHR] = 2.9, 95% confidence interval [CI] = 1.0-8.2, P = 0.04), septic shock (AHR = 5.7, 95% CI = 1.6-20.3, P = 0.007), and dysfunction of three or more organs (AHR = 2.9, 95% CI = 1.1-7.3, P = 0.03) increased the risk of in-hospital mortality. Adding aggregate organ dysfunction to the multivariate equation that included the sepsis category statistically significantly improved the model, but the opposite did not. Predictors of mortality were easily measurable and could be used to risk stratify critically ill patients in resource-constrained settings.

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Figures

Figure 1.
Figure 1.
In-hospital mortality according to sepsis category and aggregate organ dysfunction.
Figure 2.
Figure 2.
Survival curves for in-hospital mortality according to aggregate organ dysfunction.
Figure 3.
Figure 3.
Receiver-operating characteristic curves of aggregate organ dysfunction and sepsis category prediction of in-hospital mortality.
See this image and copyright information in PMC

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