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. 2011 Jul;18(2):87-93.
doi: 10.4103/0971-6580.84258.

Mechanisms pertaining to arsenic toxicity

Amrit Pal Singh  1 , Rajesh Kumar Goel, Tajpreet Kaur
Affiliations

Mechanisms pertaining to arsenic toxicity

Amrit Pal Singh et al. Toxicol Int. 2011 Jul.

Abstract

Arsenic is an environmental pollutant and its contamination in the drinking water is considered as a serious worldwide environmental health threat. The chronic arsenic exposure is a cause of immense health distress as it accounts for the increased risk of various disorders such as cardiovascular abnormalities, diabetes mellitus, neurotoxicity, and nephrotoxicity. In addition, the exposure to arsenic has been suggested to affect the liver function and to induce hepatotoxicity. Moreover, few studies demonstrated the induction of carcinogenicity especially cancer of the skin, bladder, and lungs after the chronic exposure to arsenic. The present review addresses diverse mechanisms involved in the pathogenesis of arsenic-induced toxicity and end-organ damage.

Keywords: Arsenic; carcinogenicity; cardiovascular dysfunction; diabetes; hepatotoxicity; nephrotoxicity; neurotoxicity.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Pathological mechanisms involved in arsenic-induced cardiovascular dysfunction
Figure 2
Figure 2
Pathological mechanisms involved in arsenic-induced diabetes
Figure 3
Figure 3
Pathological mechanisms involved in arsenic-induced neurotoxicity
Figure 4
Figure 4
Pathological mechanisms involved in arsenic-induced hepatotoxicity and nephrotoxicity
Figure 5
Figure 5
Pathological mechanisms involved in arsenic-induced carcinogenicity
See this image and copyright information in PMC

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