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. 2011 Jul;4(2):139-44.
doi: 10.4103/0974-2069.84652.

Percutaneous closure of patent ductus arteriosus in children: Immediate and short-term changes in left ventricular systolic and diastolic function

Saurabh Kumar Gupta  1 , Km Krishnamoorthy, Jaganmohan A Tharakan, S Sivasankaran, G Sanjay, S Bijulal, T Anees
Affiliations

Percutaneous closure of patent ductus arteriosus in children: Immediate and short-term changes in left ventricular systolic and diastolic function

Saurabh Kumar Gupta et al. Ann Pediatr Cardiol. 2011 Jul.

Abstract

Objective: To evaluate the effect of percutaneous closure of patent ductus arteriosus (PDA) on left ventricular (LV) systolic and diastolic function in children.

Background: Limited studies are available on alteration in LV hemodynamics, especially diastolic function, after PDA closure.

Methods: Thirty-two consecutive children with isolated PDA treated by trans-catheter closure were studied. The LV systolic and diastolic function were assessed by two-dimensional (2D) echocardiography and tissue Doppler imaging 1 day before the PDA closure, on day 1, and on follow-up.

Results: At baseline, none of the patients had LV systolic dysfunction. On day 1 post-PDA closure, 8 (25%) children developed LV systolic dysfunction. The baseline LV ejection fraction (LVEF), LV end-systolic dimension (LVESD), and PDA diastolic gradient predicted the post-closure LVEF. Patients who developed post-closure LV systolic dysfunction had poorer LV diastolic function than those who did not. LV diastolic properties improved after PDA closure; however, the improvement in LV diastolic properties lagged behind the improvement in the LV systolic function. All children were asymptomatic and had normal LVEF on follow up of >3 months.

Conclusions: Percutaneous closure of PDA is associated with the reversible LV systolic dysfunction. Improvement in the LV diastolic function lags behind that in the LV systolic function.

Keywords: Diastolic dysfunction; left ventricular systolic dysfunction; patent ductus arteriosus.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Baseline characteristics of patients without and with postclosure LV systolic dysfunction
Figure 2
Figure 2
Comparison of LV volumes and systolic function in patients with (a), or without (b) postclosure LV dysfunction
See this image and copyright information in PMC

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