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. 2009:2009:bcr12.2008.1381.
doi: 10.1136/bcr.12.2008.1381. Epub 2009 Oct 5.

Acute profound abciximab induced thrombocytopenia: a correct management of a methodological error

Gaetano Tanzilli  1 , Martina Sordi, Alessio Arrivi, Enrico Mangieri, Massimiliano Scappaticci
Affiliations

Acute profound abciximab induced thrombocytopenia: a correct management of a methodological error

Gaetano Tanzilli et al. BMJ Case Rep. 2009.

Abstract

Thrombocytopenia is a rare complication of glycoprotein IIb/IIIa treatment. We report a case of an acute profound abciximab induced thrombocytopenia and its successful management. The patient, presenting with unstable angina, underwent percutaneous coronary intervention with implantation of three drug eluting stents without receiving a clopidogrel loading dose according to guidelines. The rapid drop in the platelet count after abciximab elastomeric pump infusion was treated with drug discontinuation and platelet transfusion. The high risk of stent thrombosis was avoided by a timely readministration of the dual antiplatelet treatment.

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Figures

Figure 1
Figure 1
Graph showing the early drop in the platelet count, the appearance of micro-haematuria, and the subsequent rise in platelets.
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