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. 2011 Jan;6(1):2-3.
doi: 10.4103/1817-1745.84398.

T-cell epitope finding on EPHA2 for further glioma vaccine development: An immunomics study

Viroj Wiwanitkit  1
Affiliations

T-cell epitope finding on EPHA2 for further glioma vaccine development: An immunomics study

Viroj Wiwanitkit. J Pediatr Neurosci. 2011 Jan.

Abstract

Background: Glioma is a deadly neurological tumor. For modern management of glioma, glioma vaccinotherapy is the new concept.

Materials and methods: Based on present biomedical technique, the identification of T-cell epitopes via MHC mapping can help clarify the inter-relationship of tumor and immune system. This process can be performed using advanced immunoinformatics technique.

Results: Here, the author performs an immunoinformatics analysis to find alternative epitopes for glioma-related antigen, EPHA2.

Conclusion: After complete manipulation on EPHA2 molecules, the five best epitopes were derived.

Keywords: Epitope; T cell; glioma; vaccine.

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Conflict of interest statement

Conflict of Interest: None declared.

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