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. 2011 Oct 7;11(11):792-804.
doi: 10.1038/nrc3139.

TRIM proteins and cancer

Shigetsugu Hatakeyama  1
Affiliations

TRIM proteins and cancer

Shigetsugu Hatakeyama. Nat Rev Cancer. .

Abstract

Emerging clinical evidence shows that the deregulation of ubiquitin-mediated degradation of oncogene products or tumour suppressors is likely to be involved in the aetiology of carcinomas and leukaemias. Recent studies have indicated that some members of the tripartite motif (TRIM) proteins (one of the subfamilies of the RING type E3 ubiquitin ligases) function as important regulators for carcinogenesis. This Review focuses on TRIM proteins that are involved in tumour development and progression.

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