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. 2011 Dec;13(12):1370-8.
doi: 10.1093/neuonc/nor120. Epub 2011 Oct 6.

Descriptive epidemiology of CNS tumors in France: results from the Gironde Registry for the period 2000-2007

I Baldi  1 , A Gruber, A Alioum, E Berteaud, P Lebailly, A Huchet, T Tourdias, G Kantor, J P Maire, A Vital, H Loiseau; Gironde TSNC Registry Group
Collaborators, Affiliations

Descriptive epidemiology of CNS tumors in France: results from the Gironde Registry for the period 2000-2007

I Baldi et al. Neuro Oncol. 2011 Dec.

Abstract

An increase in the incidence of CNS tumors has been observed in many countries in the last decades. The reality of this trend has been much debated, as it has happened during a period when computer-assisted tomography and MRI have dramatically improved the detection of these tumors. The Gironde CNS Tumor Registry provides here the first data on CNS tumor incidence and trends in France for all histological types, including benign and malignant tumors, for the period 2000-2007. Incidence rates were calculated globally and for each histological subtype. For trends, a piecewise log-linear model was used. The overall annual incidence rate was found to be 17.6/100 000. Of this rate, 7.9/100 000 were neuroepithelial tumors and 6.0/100 000 were meningiomas. An overall increase in CNS tumor incidence was observed from 2000 to 2007, with an annual percent change (APC) of +2.33%, which was explained mainly by an increase in the incidence of meningiomas over the 8-year period (APC = +5.4%), and also more recently by an increase in neuroepithelial tumors (APC = +7.45% from 2003). The overall increase was more pronounced in women and in the elderly, with an APC peaking at +24.65% in subjects 85 and over. The increase in the incidence rates we observed may have several explanations: not only improvements in registration, diagnosis, and clinical practice, but also changes in potential risk factors.

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Figures

Fig. 1.
Fig. 1.
Annual incidence of CNS tumor by age and sex, Gironde CNS Tumor Registry, 2000–2007. formula image Men formula image Women formula image Total.
Fig. 2.
Fig. 2.
Distribution of main histological types by sex and age, Gironde CNS Tumor Registry, 2000–2007. formula image Neuroepithelial tumors, formula image meningeal tumors, formula image cranial and spinal nerve tumors, formula image lymphomas, formula image others (local extension from regional tumors, craniopharyngiomas, germ cell tumors and cysts, unclassified tumors.
Fig. 3.
Fig. 3.
Trends in crude incidence by age group and by sex, Gironde CNS Tumor Registry, 2000–2007. formula image 0–14 y  formula image 25–64 y formula image 15–24  formula image 65–84 y formula image ≥ 85 y. formula image Women formula image Men.
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