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. 1978;26(1-6):509-12.

Studies on the mode of action of IME--an inhibitor of interferon activity from mouse embryo tissues

M Cembrzyńska-Nowak
  • PMID: 219807

Studies on the mode of action of IME--an inhibitor of interferon activity from mouse embryo tissues

M Cembrzyńska-Nowak. Arch Immunol Ther Exp (Warsz). 1978.

Abstract

IME--inhibitor of interferon activity from mouse embryo tissues does not inactive interferon by direct contact; it does not inhibit the production of interferon and it does not affect the replication of challenge virus. IME shows no species-specific activity since it exhibits anti-interferon action not only in homologous interferon system but also in the heterologous rat, chick and human interferon systems. The interferon-induced antiviral state as well as the efficient cell's metabolism appear to be necessary for the expression of activity of IME.

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