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Comment
. 2011 Oct 5;14(4):435-6.
doi: 10.1016/j.cmet.2011.09.003.

Estrogens and obesity: is it all in our heads?

Sarah Hart-Unger  1 , Kenneth S Korach
Affiliations
Comment

Estrogens and obesity: is it all in our heads?

Sarah Hart-Unger et al. Cell Metab. .

Abstract

Estrogens have preventative effects on weight gain and associated comorbidities, but the tissue-specific targets remain unknown. Here, Xu et al. (2011) demonstrate that ablation of estrogen signaling in two populations of hypothalamic neurons leads to weight gain and subsequent metabolic dysregulation and could be important target sites of estrogen actions.

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Figures

Figure 1
Figure 1. Effects of hypothalamic estrogen signaling on body weight
A schematic illustrating three outcomes of estrogen signaling mediated through ERα via two populations of hypothalamic neurons as demonstrated in the following study by Xu et al., all of which lead to maintaining a proper body weight.
See this image and copyright information in PMC

Comment on

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