Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Oct 9;8(11):945-7.
doi: 10.1038/nmeth.1710.

Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain

Alexandre Kuhn  1 , Doris Thu, Henry J Waldvogel, Richard L M Faull, Ruth Luthi-Carter
Affiliations

Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain

Alexandre Kuhn et al. Nat Methods. .

Abstract

Human diseases are often accompanied by histological changes that confound interpretation of molecular analyses and identification of disease-related effects. We developed population-specific expression analysis (PSEA), a computational method of analyzing gene expression in samples of varying composition that can improve analyses of quantitative molecular data in many biological contexts. PSEA of brains from individuals with Huntington's disease revealed myelin-related abnormalities that were undetected using standard differential expression analysis.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1988 Aug;85(15):5733-7 - PubMed
    1. BMC Bioinformatics. 2005 Mar 14;6:54 - PubMed
    1. Nat Methods. 2010 Apr;7(4):287-9 - PubMed
    1. Hum Mol Genet. 2006 Mar 15;15(6):965-77 - PubMed
    1. PLoS One. 2009 Jul 01;4(7):e6098 - PubMed

Publication types

Associated data