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. 2011 Sep 21;52(38):4821-4823.
doi: 10.1016/j.tetlet.2011.06.115.

A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations

Muhammad Ayaz  1 , Justin Dietrich, Christopher Hulme
Affiliations

A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations

Muhammad Ayaz et al. Tetrahedron Lett. .

Abstract

This communication reveals an innovative and facile procedure to prepare quinoxalines in two synthetic steps. The microwave assisted Petasis reaction is followed by the acid mediated unmasking of an internal amino nucleophile, cyclodehydration and oxidation to give collections of quinoxalines in good to excellent yields.

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Figures

Scheme 1
Scheme 1. Model Petasis Reaction
Scheme 2
Scheme 2. Boc removal and cyclodehydration-oxidation
Scheme 2
Scheme 2. Two step sequence to Quinoxalines
See this image and copyright information in PMC

References

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