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. 2011 Oct;10(10):1389-92.
doi: 10.1586/erv.11.106.

Mucosal immunity to poliovirus

Pearay L Ogra  1 , Hiromasa Okayasu, Cecil Czerkinsky, Roland W Sutter
Affiliations

Mucosal immunity to poliovirus

Pearay L Ogra et al. Expert Rev Vaccines. 2011 Oct.

Abstract

The Global Polio Eradication Initiative (GPEI) currently based on use of oral poliovirus vaccine (OPV) has identified suboptimal immunogenicity of this vaccine as a major impediment to eradication, with a failure to induce protection against paralytic poliomyelitis in certain population segments in some parts of the world. The Mucosal Immunity and Poliovirus Vaccines: Impact on Wild Poliovirus Infection, Transmission and Vaccine Failure conference was organized to obtain a better understanding of the current status of global control of poliomyelitis and identify approaches to improve the immune responsiveness and effectiveness of the orally administered poliovirus vaccines in order to accelerate the global eradication of paralytic poliomyelitis.

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