Tissue engineering tools for modulation of the immune response
- PMID: 21988690
- PMCID: PMC3526814
- DOI: 10.2144/000113754
Tissue engineering tools for modulation of the immune response
Abstract
Tissue engineering scaffolds have emerged as a powerful tool within regenerative medicine. These materials are being designed to create environments that promote regeneration through a combination of: (i) scaffold architecture, (ii) the use of scaffolds as vehicles for transplanting progenitor cells, and/or (iii) localized delivery of inductive factors or genes encoding for these inductive factors. This review describes the techniques associated with each of these components. Additionally, the immune response is increasingly recognized as a factor influencing regeneration. The immune reaction to an implant begins with an acute response to the injury and innate recognition of foreign materials, with the subsequent chronic immune response involving specific recognition of antigens (e.g., transplanted cells) by the adaptive immune response, which can eventually lead to rejection of the implant. Thus, we also describe the impact of each component on the immune response, and strategies (e.g., material design, anti-inflammatory cytokine delivery, and immune cell recruitment/transplantation) to modulate, yet not eliminate, the local immune response in order to promote regeneration, which represents another important tool for regenerative medicine.
Figures


Similar articles
-
Development and therapeutic applications of advanced biomaterials.Curr Opin Biotechnol. 2007 Oct;18(5):454-9. doi: 10.1016/j.copbio.2007.09.008. Epub 2007 Nov 5. Curr Opin Biotechnol. 2007. PMID: 17981454 Review.
-
Polymers to direct cell fate by controlling the microenvironment.Curr Opin Biotechnol. 2007 Oct;18(5):448-53. doi: 10.1016/j.copbio.2007.10.004. Curr Opin Biotechnol. 2007. PMID: 18024105 Free PMC article. Review.
-
Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response.Trends Biotechnol. 2016 Jun;34(6):470-482. doi: 10.1016/j.tibtech.2016.03.009. Epub 2016 Apr 29. Trends Biotechnol. 2016. PMID: 27138899 Review.
-
Controlled release strategies for modulating immune responses to promote tissue regeneration.J Control Release. 2015 Dec 10;219:155-166. doi: 10.1016/j.jconrel.2015.08.014. Epub 2015 Aug 8. J Control Release. 2015. PMID: 26264833 Free PMC article. Review.
-
Alginate microgels as delivery vehicles for cell-based therapies in tissue engineering and regenerative medicine.Carbohydr Polym. 2021 Aug 15;266:118128. doi: 10.1016/j.carbpol.2021.118128. Epub 2021 Apr 28. Carbohydr Polym. 2021. PMID: 34044944 Review.
Cited by
-
In vivo biocompatibility evaluation of electrospun composite scaffolds by subcutaneous implantation in rat.Drug Deliv Transl Res. 2013 Dec;3(6):504-17. doi: 10.1007/s13346-013-0153-z. Drug Deliv Transl Res. 2013. PMID: 25786371
-
Regenerative medicine: Current therapies and future directions.Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14452-9. doi: 10.1073/pnas.1508520112. Proc Natl Acad Sci U S A. 2015. PMID: 26598661 Free PMC article. Review.
-
Biocompatibility of nanomaterials and their immunological properties.Biomed Mater. 2021 Mar 11;16(4):10.1088/1748-605X/abe5fa. doi: 10.1088/1748-605X/abe5fa. Biomed Mater. 2021. PMID: 33578402 Free PMC article. Review.
-
Structural properties of scaffolds: Crucial parameters towards stem cells differentiation.World J Stem Cells. 2015 May 26;7(4):728-44. doi: 10.4252/wjsc.v7.i4.728. World J Stem Cells. 2015. PMID: 26029344 Free PMC article. Review.
-
Biological Properties and Biomedical Applications of Pectin and Pectin-Based Composites: A Review.Molecules. 2023 Dec 6;28(24):7974. doi: 10.3390/molecules28247974. Molecules. 2023. PMID: 38138464 Free PMC article. Review.
References
-
- Drury JL, Mooney DJ. Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials. 2003;24:4337–4351. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources