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Comment
. 2011 Oct 11;17(10):1178-9; author reply 1179-80.
doi: 10.1038/nm.2495.

Fractional synthesis and clearance rates for amyloid β

Steven D Edland, Douglas R Galasko
Comment

Fractional synthesis and clearance rates for amyloid β

Steven D Edland et al. Nat Med. .
No abstract available

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Conflict of interest statement

COMPETING FINANCIAL INTERESTS

The authors declare no competing financial interests.

Figures

Figure 1.
Figure 1.
During the infusion of 13C6-labeled leucine, the fraction of labeled Aβ secreted by neurons increases from 0% to a theoretical maximum of 10% at the neuronal fractional synthesis rate. Within the brain, secreted molecules are cleared by processes that do not discriminate labeled from unlabeled molecules and do not influence the fraction that is labeled. Labeled molecules leaving the brain are diluted by a large volume of CSF containing unlabeled Aβ before being sampled from the lumbar subarachnoid space.
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References

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    1. Bateman RJ et al. Ann. Neurol. 66, 48–54 (2009). - PMC - PubMed
    1. Mawuenyega KG et al. Science 330, 1774 (2010). - PMC - PubMed

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