Prefrontal systems involvement in binge eating

Abstract

Objective: This study examined whether severity of binge eating is associated with dysfunction in behaviors mediated by the three main areas of the prefrontal cortex (PFC).

Methods: One hundred fifty-one adults (mean BMI=49.50) were classified into three groups based on the presence and severity of binge eating behaviors: Binge Eating Disorder (BED) group (N=22), Binge Eating Prone (BEP) group (N=47), and non-Eating Disorder (non-ED) group (N=82). Participants completed the Frontal Systems Behavior Scale (FrSBe), a widely used measure of neurobehavioral traits associated with the three primary regions of the PFC corresponding with the behavioral traits of apathy, disinhibition, and executive dysfunction.

Results: The BED and BEP groups scored significantly higher than the non-ED group on the three FrSBe subscales, as well as the FrSBe Total score. There were no significant correlations between the FrSBe and participant BMI.

Discussion: As expected, individuals who engaged in binge eating endorsed greater PFC dysfunction than those who did not binge eat. These results provide a complement to studies utilizing neuroimaging and neuropsychological methodologies and further support for the role of prefrontal systems in the regulation of eating behavior.