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. 2011:2011:756292.
doi: 10.5402/2011/756292. Epub 2011 Jul 6.

Diagnosis and therapy of microscopic colitis with presence of foamy macrophages in children

Jan Józefczuk  1 , Bogdan Marian Woźniewicz
Affiliations

Diagnosis and therapy of microscopic colitis with presence of foamy macrophages in children

Jan Józefczuk et al. ISRN Gastroenterol. 2011.

Abstract

We discuss the diagnosis of and efficacy 5-amino-2-hydroxybenzoic acid (5-ASA), Saccharomyces boulardii, or magnesium in therapy of microscopic colitis with presence of foamy macrophages. A basis for diagnosis and inclusion to the analysed group was presence of characteristic foamy macrophages in histopathological examination of hematoxylin and eosin-stained specimens collected from the large intestine, reviewed under ×200 or ×320 magnification. No statistically significant improvement was found following the use of 5-amino-2-dihydroxybenzoic acid in therapy of the disease. The use of Saccharomyces boulardii was associated with statistically significant improvement in clinical, endoscopic, and histopathological condition. Use of magnesium caused a histological, statistically significant improvement but failed to have any effect on the clinical and endoscopic presentation. In the group of children in whom no therapeutic intervention was provided, a statistically significant spontaneous clinical improvement was observed, but no statistically significant changes in endoscopic and microscopic condition were found.

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Figures

Figure 1
Figure 1
(a–d) Microscopic features of colitis with presence of foamy macrophages—characteristic large, clear cells with a small nucleus, single or aggregated within the lamina propria. HE staining. Magnification ×200.
Figure 2
Figure 2
(a–d) Immunochemistry. (a-b) positive with a serum marking macrophages. C-negative to limfocytes T. D-neurofilament's negative reaction. Magnification ×200 (a) ×320 (b, c, d).
Figure 3
Figure 3
Clinical, endoscopic, and microscopic evaluation at diagnosis (Whitney-Mann test).
Figure 4
Figure 4
Clinical, endoscopic, and microscopic evaluation of children treated with 5-amino-2-hydroxybenzoic acid (group A).
Figure 5
Figure 5
Clinical, endoscopic, and microscopic evaluation of children treated with Saccharomyces boulardii (group B).
Figure 6
Figure 6
Clinical, endoscopic, and microscopic evaluation of untreated children (group C).
Figure 7
Figure 7
Clinical, endoscopic, and microscopic evaluation of children treated with magnesium (group D).
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