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. 2011 Sep 1;2(9):2709-20.
doi: 10.1364/BOE.2.002709. Epub 2011 Aug 29.

Corneal topography with high-speed swept source OCT in clinical examination

Karol Karnowski, Bartlomiej J Kaluzny, Maciej Szkulmowski, Michalina Gora, Maciej Wojtkowski

Corneal topography with high-speed swept source OCT in clinical examination

Karol Karnowski et al. Biomed Opt Express. .

Abstract

We present the applicability of high-speed swept source (SS) optical coherence tomography (OCT) for quantitative evaluation of the corneal topography. A high-speed OCT device of 108,000 lines/s permits dense 3D imaging of the anterior segment within a time period of less than one fourth of second, minimizing the influence of motion artifacts on final images and topographic analysis. The swept laser performance was specially adapted to meet imaging depth requirements. For the first time to our knowledge the results of a quantitative corneal analysis based on SS OCT for clinical pathologies such as keratoconus, a cornea with superficial postinfectious scar, and a cornea 5 months after penetrating keratoplasty are presented. Additionally, a comparison with widely used commercial systems, a Placido-based topographer and a Scheimpflug imaging-based topographer, is demonstrated.

Keywords: (170.3880) Medical and biological imaging; (170.4470) Ophthalmology; (170.4500) Optical coherence tomography.

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Figures

Fig. 1
Fig. 1
Diagram of SS OCT setup for anterior segment imaging (FMDL, swept laser with optical delay line; OSA, optical spectrum analyzer; FC, fiber coupler; C, circulator; DBPD, dual-balanced photo diode; NDF, neutral density filter; GP, glass plate; GS, xy galvo scanners. (a) Optical spectrum of FDML laser constructed at Nicolaus Copernicus University.
Fig. 2
Fig. 2
SS OCT images of a flat surface measured in two perpendicular directions, (a) horizontally and (b) vertically, after optical distortion correction. (c) En face projection image from 3-D OCT data for graph paper in a 9 mm × 9 mm area.
Fig. 3
Fig. 3
(a–b) central OCT images of the reference sphere; (c) photograph of the reference sphere with 7.94 mm radius of curvature. (d) Radius of curvature for nine different OCT measurements; diamonds, mean value; red line, radius given by manufacturer.
Fig. 4
Fig. 4
Qualitative evaluation of a keratoconic cornea with three different instruments. K1, K2, central keratometry readings. The red lines on Scheimpflug images correspond to the lateral size of cross-sectional images for SS OCT.
Fig. 5
Fig. 5
Qualitative evaluation of a cornea with superficial postinfectious scar with three different instruments. K1, K2, central keratometry readings. The red lines on Scheimpflug images correspond to the lateral size of cross-sectional images for SS OCT.
Fig. 6
Fig. 6
Cross-sectional images of the cornea with superficial postinfectious scar: (a) Scheimpflug image measured by Pentacam HR; (b) SS OCT cross-sectional image. Red lines delineate the segmented corneal boundaries.
Fig. 7
Fig. 7
Qualitative evaluation of a cornea 5 months after penetrating keratoplasty with three different instruments. K1, K2, central keratometry readings. The red lines on Scheimpflug images correspond to the lateral size of cross-sectional images from SS OCT.
Fig. 8
Fig. 8
Cross-sectional images of the cornea after penetrating keratoplasty: (a) Scheimpflug image measured by Pentacam HR, (b) SS OCT cross-sectional image. Red lines delineate the segmented corneal boundaries.
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