Review
doi: 10.1016/0306-3623(90)90686-g.
Release of intracellularly stored Ca2+ by inositol 1,4,5-trisphosphate--an overview
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- PMID: 2199296
- DOI: 10.1016/0306-3623(90)90686-g
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Review
Release of intracellularly stored Ca2+ by inositol 1,4,5-trisphosphate--an overview
Gen Pharmacol.
1990.
Abstract
1. Inositol 1,4,5-trisphosphate (I(1,4,5)P3) releases Ca2+ from ATP-dependent Ca2+ stores in permeabilized cells and in microsomal fractions. 2. Various factors affect the amount of Ca2+ released by I(1,4,5)P3. 3. The molecular mechanism involved in the I(1,4,5)P3-induced Ca2+ release is now being investigated and I(1,4,5)P3-specific receptors and/or specific release channels are being given special attention. 4. While the I(1,4,5)P3-sensitive Ca2+ stores are presumed to locate at the endoplasmic reticulum, the relation between the I(1,4,5)P3- and the agonist-sensitive Ca2+ stores remains to be elucidated.
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