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. 2011 Dec;34(12):2594-6.
doi: 10.2337/dc11-1620. Epub 2011 Oct 12.

Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients

Kasper Broedbaek  1 , Volkert Siersma, Trine Henriksen, Allan Weimann, Morten Petersen, Jon T Andersen, Espen Jimenez-Solem, Elisabeth S Stovgaard, Lars J Hansen, Jan Erik Henriksen, Steen J Bonnema, Niels de Fine Olivarius, Henrik E Poulsen
Affiliations

Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients

Kasper Broedbaek et al. Diabetes Care. 2011 Dec.

Abstract

Objective: We analyzed data from a cohort of 1,381 newly diagnosed type 2 diabetic patients to test the hypothesis that urinary markers of nucleic acid oxidation are independent predictors of mortality.

Research design and methods: We examined the relationship between urinary excretion of markers of DNA oxidation (8-oxo-7,8-dihydro-2'-deoxyguanosine [8-oxodG]) and RNA oxidation (8-oxo-7,8-dihydroguanosine [8-oxoGuo]) and long-term mortality using Cox proportional hazards regression.

Results: After multivariate adjustment, the hazard ratios for all-cause and diabetes-related mortality of patients with 8-oxoGuo levels in the highest quartile compared with those in the lowest quartile were 1.44 (1.12-1.85) and 1.54 (1.13-2.10), respectively. Conversely, no significant associations between 8-oxodG and mortality were found in the adjusted analyses.

Conclusions: Urinary excretion of the RNA oxidation marker 8-oxoGuo measured shortly after diagnosis of type 2 diabetes predicts long-term mortality independently of conventional risk factors. This finding suggests that 8-oxoGuo could serve as a new clinical biomarker in diabetes.

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