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. 2010 Dec;2(12):2649-62.
doi: 10.3390/v2122649. Epub 2010 Dec 8.

The complexity of antibody-dependent enhancement of dengue virus infection

Maria G Guzman  1 , Susana Vazquez
Affiliations

The complexity of antibody-dependent enhancement of dengue virus infection

Maria G Guzman et al. Viruses. 2010 Dec.

Abstract

Antibody-dependent enhancement (ADE) has been proposed as a mechanism to explain dengue hemorrhagic fever (DHF) in the course of a secondary dengue infection. Very recently, Dejnirattisai et al., 2010 [1], published an important article supporting the involvement of anti-prM antibodies in the ADE phenomenon. The complexity of ADE in the context of a secondary dengue infection is discussed here.

Keywords: ADE; cleavage; dengue; dengue hemorrhagic fever; neutralization; prM.

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Figures

Figure 1
Figure 1
Schematic representation of viral populations and anti-E and anti-prM antibodies involved in neutralization and ADE mechanism. Immature ( formula image), partially mature ( formula image), mature ( formula image) viral particles, neutralizing anti-E antibodies ( formula image), cross-reactive non-neutralizing anti-E antibodies ( formula image) and cross reactive anti-prM antibodies ( formula image).
See this image and copyright information in PMC

References

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