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. 2011 Mar;3(3):272-277.
doi: 10.3390/v3030272. Epub 2011 Mar 15.

Paradoxical interplay of viral and cellular functions

Esteban Domingo  1   2
Affiliations

Paradoxical interplay of viral and cellular functions

Esteban Domingo. Viruses. 2011 Mar.

Abstract

Some cellular editing functions can restrict the replication of some viruses but contribute to completion of the life cycle of others. A recent study has identified an isoform of the adenosine deaminase acting on RNA type 1 (ADAR 1) as required for embryogenesis, and as a restriction factor for a number of important RNA virus pathogens. The dual implication of key cellular functions in the innate immunity against viruses, or, paradoxically, as mediators of virus replication is interpreted in the light of the concept of virus-host coevolution and tinkering proposed for general evolution by François Jacob decades ago.

Keywords: RNA virus; coevolution; host-virus interaction.

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References

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