Maternal and neonatal outcomes following induction of labor: a cohort study

Abstract

Objective: To evaluate maternal and neonatal outcomes associated with birth at term by week of gestational age and also by onset of labor.

Design: Cohort study.

Setting: A state-wide perinatal outcome database.

Population: 28,626 women with spontaneous onset of labor, induction of labor for recognized indications and induction of labor for non-recognized indications.

Methods: Cohort study utilizing a validated dataset comparing outcomes with type of onset of labor using a log binomial model.

Main outcome measures: Cesarean section, assisted vaginal birth, important measures of maternal and neonatal morbidity.

Results: Induction of labor for non-recognized indications was associated with a significantly increased risk of a range of outcomes, including cesarean section (RR 1.67, 95% CI 1.55-1.80). The lowest risk of adverse maternal and infant outcome occurred with birth between 38 and 39 weeks and with the spontaneous onset of labor.

Conclusions: Induction of labor for non-recognized indications at term is associated with an increased risk of adverse outcomes. Caution is warranted with a liberal policy of induction of labor at term in an otherwise uncomplicated pregnancy.