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Review
. 2011 Dec;141(3):253-67.
doi: 10.1016/j.clim.2011.09.002. Epub 2011 Sep 17.

The role of naïve T-cells in HIV-1 pathogenesis: an emerging key player

Gabriela Khoury  1 , Reena Rajasuriar, Paul U Cameron, Sharon R Lewin
Affiliations
Review

The role of naïve T-cells in HIV-1 pathogenesis: an emerging key player

Gabriela Khoury et al. Clin Immunol. 2011 Dec.

Abstract

Functional naïve T-cells are critical for an effective immune response to multiple pathogens. HIV leads to a significant reduction in CD4+ naïve T-cell number and impaired function and there is incomplete recovery following combination antiretroviral therapy (cART). Here we review the basic homeostatic mechanisms that maintain naïve CD4+ T-cells and discuss recent developments in understanding the impact of HIV infection on naïve CD4+ T-cells. Finally we review therapeutic interventions in HIV-infected individuals aimed at specifically enhancing recovery of naïve CD4+ T-cells.

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