Lead identification: Keeping tetramers together

Comment

Monica Hoyos Flight. Nat Rev Drug Discov. 2011.

. 2011 Oct 14;10(11):816.

doi: 10.1038/nrd3586.

No abstract available

Comment on

Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity.
Alhamadsheh MM, Connelly S, Cho A, Reixach N, Powers ET, Pan DW, Wilson IA, Kelly JW, Graef IA. Alhamadsheh MM, et al. Sci Transl Med. 2011 Aug 24;3(97):97ra81. doi: 10.1126/scitranslmed.3002473. Sci Transl Med. 2011. PMID: 21865539 Free PMC article.

Construction of molecular assemblies via docking: modeling of tetramers with D2 symmetry.
Berchanski A, Eisenstein M. Berchanski A, et al. Proteins. 2003 Dec 1;53(4):817-29. doi: 10.1002/prot.10480. Proteins. 2003. PMID: 14635124
Functional cross-linked hemoglobin bis-tetramers: geometry and cooperativity.
Hu D, Kluger R. Hu D, et al. Biochemistry. 2008 Nov 25;47(47):12551-61. doi: 10.1021/bi801452b. Biochemistry. 2008. PMID: 18956893
Cross-linked bis-hemoglobins: connections and oxygen binding.
Gourianov N, Kluger R. Gourianov N, et al. J Am Chem Soc. 2003 Sep 10;125(36):10885-92. doi: 10.1021/ja036596i. J Am Chem Soc. 2003. PMID: 12952468
Conjoined hemoglobins. Loss of cooperativity and protein-protein interactions.
Gourianov N, Kluger R. Gourianov N, et al. Biochemistry. 2005 Nov 15;44(45):14989-99. doi: 10.1021/bi0513812. Biochemistry. 2005. PMID: 16274245
Use of HLA-B27 tetramers to identify low-frequency antigen-specific T cells in Chlamydia-triggered reactive arthritis.
Appel H, Kuon W, Kuhne M, Wu P, Kuhlmann S, Kollnberger S, Thiel A, Bowness P, Sieper J. Appel H, et al. Arthritis Res Ther. 2004;6(6):R521-34. doi: 10.1186/ar1221. Epub 2004 Sep 23. Arthritis Res Ther. 2004. PMID: 15535830 Free PMC article.