Prevention and treatment of MS: studying the effects of vitamin D
- PMID: 21998006
- PMCID: PMC3351202
- DOI: 10.1177/1352458511425366
Prevention and treatment of MS: studying the effects of vitamin D
Erratum in
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Corrigendum.Mult Scler. 2016 Oct;22(12):NP6. doi: 10.1177/1352458511434380. Epub 2011 Dec 22. Mult Scler. 2016. PMID: 22194215
Abstract
Observational studies suggest that adequate vitamin D nutrition may reduce the risk of MS and affect the course of the disease. Inherent limitations in these studies, however, preclude a causal interpretation. Randomized controlled clinical trials are the next step to addressing whether vitamin D prevents MS or can favorably affect the course and progression of MS. Here we briefly review the current literature on vitamin D and MS, both as a risk factor and potential treatment for MS with a focus on the issues and challenges in designing prevention and treatment clinical trials.
References
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- Goldberg P. Multiple sclerosis: vitamin D and calcium as environmental determinants of prevalence (A viewpoint) Part 1: sunlight, dietary factors and epidemiology. Intern J Environmental Studies. 1974;6:19–27.
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- Ascherio A, Munger KL, Simon KC. Vitamin D and multiple sclerosis. Lancet Neurol. 2010;9(6):599–612. - PubMed
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