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Comment
. 2011 Dec 15;204(12):1822-6.
doi: 10.1093/infdis/jir653. Epub 2011 Oct 12.

Time to refocus on HSV interventions for HIV prevention?

Clare Tanton, Laith J Abu-Raddad, Helen A Weiss
Comment

Time to refocus on HSV interventions for HIV prevention?

Clare Tanton et al. J Infect Dis. .
No abstract available

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Figures

Figure 1.
Figure 1.
Impact of high-dose valacylovir treatment on human immunodeficiency virus (HIV) transmission and the HIV epidemic. A, The reduction in HIV transmission probability per coital act expected with a reduction in HIV plasma viral load. The X marker signifies the reduction in infectiousness expected with a reduction of 1 log10 copies/mL in HIV plasma viral load, similar to the viremia reduction observed by Mugwanya et al. B, Impact of intervention aimed at reducing community-level HIV plasma viral load on HIV prevalence and incidence rate at endemic equilibrium. The X marker signifies the impact on prevalence and incidence if the community-level viral load is reduced at the population level by similar magnitude to that observed in Mugwanya et al.
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References

    1. Mugwanya K, Baeten JM, Mugo NR, Irungu E, Ngure K, Celum C. High-dose valacyclovir HSV-2 suppression results in greater reduction in plasma HIV-1 levels compared to standard dose acyclovir among HIV-1/HSV-2 co-infected persons: a randomized, cross-over trial. J Infect Dis. 2011 204:1912–7. - PMC - PubMed
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