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Comment
. 2011 Oct 12;19(10):1351-3.
doi: 10.1016/j.str.2011.09.007.

PARG: a macrodomain in disguise

Markus Hassler  1 , Gytis Jankevicius, Andreas G Ladurner
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PARG: a macrodomain in disguise

Markus Hassler et al. Structure. .
Free article

Abstract

Our understanding of poly-ADP-ribosylation as a posttranslational modification was limited by the lack of structural information on poly-ADP-ribose (PAR) hydrolysing enzymes. A recent study in Nature (Slade et al., 2011) reports the structure of PAR glycohydrolase (PARG), revealing unexpected similarity to the ubiquitous ADP-ribose-binding macrodomains.

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