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. 2011 Oct 12;19(10):1353-5.
doi: 10.1016/j.str.2011.10.001.

It takes two to Get3

Irmgard Sinning  1 , Gert Bange, Klemens Wild
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It takes two to Get3

Irmgard Sinning et al. Structure. .
Free article

Abstract

Tail-anchored (TA) membrane proteins perform essential cellular functions. They are posttranslationally inserted into the endoplasmic reticulum (ER) membrane by interaction of the Get3 chaperone with the Get1/2 receptor. Two independent structural and functional analyses of the Get3/receptor complex by Stefer et al. and Mariappan et al. now provide insights into TA protein insertion.

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