Review
doi: 10.1016/0968-0004(90)90047-f.
Positively charged residues are important determinants of membrane protein topology
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- PMID: 2200169
- DOI: 10.1016/0968-0004(90)90047-f
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Review
Positively charged residues are important determinants of membrane protein topology
Trends Biochem Sci.
1990 Jul.
Abstract
Membrane proteins are found in a variety of conformations, with each protein spanning the membrane a set number of times and adopting a particular orientation. Positively charged residues, often located near the boundaries of transmembrane segments, appear to be involved in specifying the topology of membrane proteins.
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