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Meta-Analysis
. 2011 Dec;19(12):1396-404.
doi: 10.1016/j.joca.2011.09.005. Epub 2011 Oct 5.

Serum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee osteoarthritis: a systematic review and meta-analysis

J M Hoch  1 , C G Mattacola, J M Medina McKeon, J S Howard, C Lattermann
Affiliations
Meta-Analysis

Serum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee osteoarthritis: a systematic review and meta-analysis

J M Hoch et al. Osteoarthritis Cartilage. 2011 Dec.

Abstract

Objective: To be used in diagnostic studies, it must be demonstrated that biomarkers can differentiate between diseased and non-diseased patients. Therefore, the purpose of this study was to answer the following questions: (1) Is serum cartilage oligomeric matrix protein (sCOMP) elevated in patients with radiographically diagnosed knee osteoarthritis (OA) compared to controls? (2) Are there differences in sCOMP levels when comparing differing radiographic OA severities to controls?

Methods: Systematic review and meta-analysis.

Data sources: A systematic search of CINAHL, PEDro, Medline, and SportsDiscus was completed in March 2010.

Keywords: knee, osteoarthritis, sCOMP, radiography. Study inclusion criteria: Studies were written in English, compared healthy adults with knee OA patients, used the Kellgren Lawrence (K/L) classification, measured sCOMP, and reported means and standard deviations for sCOMP.

Results: For question 1, seven studies were included resulting in seven comparisons. A moderate overall effect size (ES) indicated sCOMP was consistently elevated in those with radiographically diagnosed knee OA when compared to controls (ES = 0.60, P < 0.001). For question 2, four studies were included resulting in 13 comparisons between radiographic OA severity levels and controls. Strong ESs were calculated for K/L-1 (ES = 1.43, P = 0.28), K/L-3 (ES = 1.05, P = 0.04), and K/L-4 (ES = 1.40, P = 0.003). A moderate ES was calculated for K/L-2 (ES = 0.60, P = 0.01).

Conclusions: These results indicate sCOMP is elevated in patients with knee OA and is sensitive to OA disease progression. Future research studies with a higher level of evidence should be conducted to investigate the use of this biomarker as an indicator for OA development and progression.

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Conflict of interest statement

9. Conflict of interest

There are no competing interests to disclose for any of the authors on this manuscript.

Figures

Fig. 1
Fig. 1
Summary of search history and included studies.
Fig. 2
Fig. 2
A Forest plot depicting the calculated ESs of sCOMP in patients with radiographically diagnosed knee OA when compared to controls. The diamond at the bottom of the plot represents the overall ES.
Fig. 3
Fig. 3
A funnel plot of standard error by Hedges’ g using Duval and Tweedie’s Trim and Fill method to assess publication bias of the studies used to determine if sCOMP is elevated in patients with radiographically diagnosed knee OA when compared to controls.
Fig. 4
Fig. 4
A Forest plot depicting the calculated ESs of sCOMP exist when comparing patients with differing radiographic knee OA severities compared to controls. Each of the diamonds represents the overall ES for each of the comparisons made for each (K/L) classification.
Fig. 5
Fig. 5
A funnel plot of standard error by Hedges’s g using Duval and Tweedie’s Trim and Fill method to assess publication bias of the comparisons used to determine if differences in sCOMP levels exist when comparing differing knee OA severities when compared to healthy controls.
Fig. 6
Fig. 6
A Forest plot depicting the calculated ESs for large groups ( n > 10) and small groups ( n < 10) used to answer the second question.
See this image and copyright information in PMC

References

    1. Garnero P, Delmas PD. Biomarkers in osteoarthritis. Curr Opin Rheumatol. 2003;15:641–646. - PubMed
    1. Tseng S, Reddi AH, Di Cesare PE. Cartilage oligomeric matrix protein (COMP): a biomarker of arthritis. Biomark Insights. 2009;4:33–44. - PMC - PubMed
    1. Fernandes FA, Pucinelli MLC, da Silva NP, Feldman D. Serum cartilage oligomeric matrix protein (COMP) levels in knee osteoarthritis in a Brazilian population: clinical and radiological correlation. Scand J Rheumatol. 2007;36(3):211–215. - PubMed
    1. Clark G, Jordan JM, Vilim V, Renner JB, Dragomir AD, Luta G, et al. Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project. Arthritis Rheum. 1999;42(11):2356–2364. - PubMed
    1. Palmieri-Smith RM, Thomas AC. A neuromuscular mechanism of posttraumatic osteoarthritis associated with ACL injury. Exerc Sport Sci Rev. 2009;37(3):147–153. - PubMed