Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2012 Apr;44(2):365-9.
doi: 10.1007/s11255-011-0071-2. Epub 2011 Oct 16.

Effect of intraprostatic epinephrine on intraoperative blood loss reduction during transurethral resection of the prostate

Affiliations
Randomized Controlled Trial

Effect of intraprostatic epinephrine on intraoperative blood loss reduction during transurethral resection of the prostate

Alejandro Lira-Dale et al. Int Urol Nephrol. 2012 Apr.

Abstract

Objective: To determine whether the use of intraprostatic epinephrine during transurethral resection of the prostate reduces intraoperative blood loss.

Methods: A random, double-blind, prospective study was carried out on twenty-three patients that underwent transurethral resection of the prostate. Patients were divided into two groups: (1) group receiving intraoperative intraprostatic injection of epinephrine (thirteen patients) and (2) group receiving intraoperative intraprostatic injection of saline solution as placebo (ten patients). Blood loss was quantified with the following formula: irrigation solution hemoglobin × 1000/intraoperative presurgical serum hemoglobin. The variables analyzed were blood loss, resection time, presurgical prostate volume, and grams of resected tissue. Student´s t test and Pearson correlation were used for their analysis.

Results: There were thirteen patients in the epinephrine group and ten patients in the placebo group. Mean blood loss in the epinephrine group was significantly lower than in the placebo group (127.48 mL ± 77.0 mL vs. 336.63 ± 185.6 mL, 95% CI, 45-234, P < 0.001). There were no statistically significant differences in mean resected grams or mean resection time between the two groups. One patient in the epinephrine group presented with intraoperative hypertensive crisis (7.7%).

Conclusions: Intraprostatic epinephrine injection can be used to reduce blood loss during transurethral resection of the prostate in selected patients. Cardiovascular monitoring should be carried out during its application. Resection time and grams of resected tissue continue to be the most influential factors in relation to blood loss in patients undergoing this treatment modality.

PubMed Disclaimer

Comment in

Similar articles

Cited by

References

    1. Br Med J (Clin Res Ed). 1988 Jun 11;296(6637):1631-3 - PubMed
    1. Scand J Urol Nephrol. 2009;43(5):377-82 - PubMed
    1. Br J Urol. 1986 Dec;58(6):672-5 - PubMed
    1. Gastrointest Endosc. 2008 Jun;67(7):1214; author reply 1214 - PubMed
    1. BJU Int. 2007 Mar;99(3):587-94 - PubMed

Publication types

LinkOut - more resources