Effect of intraprostatic epinephrine on intraoperative blood loss reduction during transurethral resection of the prostate
- PMID: 22002111
- DOI: 10.1007/s11255-011-0071-2
Effect of intraprostatic epinephrine on intraoperative blood loss reduction during transurethral resection of the prostate
Abstract
Objective: To determine whether the use of intraprostatic epinephrine during transurethral resection of the prostate reduces intraoperative blood loss.
Methods: A random, double-blind, prospective study was carried out on twenty-three patients that underwent transurethral resection of the prostate. Patients were divided into two groups: (1) group receiving intraoperative intraprostatic injection of epinephrine (thirteen patients) and (2) group receiving intraoperative intraprostatic injection of saline solution as placebo (ten patients). Blood loss was quantified with the following formula: irrigation solution hemoglobin × 1000/intraoperative presurgical serum hemoglobin. The variables analyzed were blood loss, resection time, presurgical prostate volume, and grams of resected tissue. Student´s t test and Pearson correlation were used for their analysis.
Results: There were thirteen patients in the epinephrine group and ten patients in the placebo group. Mean blood loss in the epinephrine group was significantly lower than in the placebo group (127.48 mL ± 77.0 mL vs. 336.63 ± 185.6 mL, 95% CI, 45-234, P < 0.001). There were no statistically significant differences in mean resected grams or mean resection time between the two groups. One patient in the epinephrine group presented with intraoperative hypertensive crisis (7.7%).
Conclusions: Intraprostatic epinephrine injection can be used to reduce blood loss during transurethral resection of the prostate in selected patients. Cardiovascular monitoring should be carried out during its application. Resection time and grams of resected tissue continue to be the most influential factors in relation to blood loss in patients undergoing this treatment modality.
Comment in
-
Comment to Lira-Dale et al.: Effect of intraprostatic epinephrine on intraoperative blood loss reduction during transurethral resection of the prostate.Int Urol Nephrol. 2012 Dec;44(6):1727; author reply 1729-30. doi: 10.1007/s11255-012-0228-7. Epub 2012 Jul 29. Int Urol Nephrol. 2012. PMID: 22843299 No abstract available.
Similar articles
-
Comment to Lira-Dale et al.: Effect of intraprostatic epinephrine on intraoperative blood loss reduction during transurethral resection of the prostate.Int Urol Nephrol. 2012 Dec;44(6):1727; author reply 1729-30. doi: 10.1007/s11255-012-0228-7. Epub 2012 Jul 29. Int Urol Nephrol. 2012. PMID: 22843299 No abstract available.
-
Transurethral resection of the prostate after intraprostatic injections of mepivacain epinephrine: a preliminary communication.Scand J Urol Nephrol. 2009;43(1):63-7. doi: 10.1080/00365590802465061. Scand J Urol Nephrol. 2009. PMID: 19085323
-
Effects of intraprostatic and periprostatic injections of mepivacaine epinephrine on intraprostatic blood flow during transurethral microwave thermotherapy: correlation with [15O]H2O-PET.J Endourol. 2004 Dec;18(10):965-70. doi: 10.1089/end.2004.18.965. J Endourol. 2004. PMID: 15801363
-
Time to rebrand transurethral resection of the prostate?Curr Opin Urol. 2006 Jan;16(1):20-4. Curr Opin Urol. 2006. PMID: 16385196 Review.
-
Impact of preoperative 5α-reductase inhibitors on perioperative blood loss in patients with benign prostatic hyperplasia: a meta-analysis of randomized controlled trials.BMC Urol. 2015 Jun 2;15:47. doi: 10.1186/s12894-015-0043-4. BMC Urol. 2015. PMID: 26032962 Free PMC article. Review.
Cited by
-
The efficacy of fibrin glue injection in the prostatic fossa on decreasing postoperative bleeding following transurethral resection of prostate.Adv Biomed Res. 2016 Oct 26;5:161. doi: 10.4103/2277-9175.192733. eCollection 2016. Adv Biomed Res. 2016. PMID: 27995100 Free PMC article.
-
The impact of irrigating fluid absorption on blood coagulation in patients undergoing transurethral resection of the prostate: A prospective observational study using rotational thromboelastometry.Medicine (Baltimore). 2017 Jan;96(2):e5468. doi: 10.1097/MD.0000000000005468. Medicine (Baltimore). 2017. PMID: 28079789 Free PMC article.
-
Comment to Lira-Dale et al.: Effect of intraprostatic epinephrine on intraoperative blood loss reduction during transurethral resection of the prostate.Int Urol Nephrol. 2012 Dec;44(6):1727; author reply 1729-30. doi: 10.1007/s11255-012-0228-7. Epub 2012 Jul 29. Int Urol Nephrol. 2012. PMID: 22843299 No abstract available.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical