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Review
. 2011 Oct 15;7(5 Suppl):S31-3.
doi: 10.5664/JCSM.1356.

Association of inflammatory markers with cardiovascular risk and sleepiness

Michelle A Miller  1
Affiliations
Review

Association of inflammatory markers with cardiovascular risk and sleepiness

Michelle A Miller. J Clin Sleep Med. .

Abstract

There is emerging evidence suggesting that disturbances in sleep and sleep disorders play a role in the morbidity of chronic conditions including obesity and hypertension as well as in the development of type-2 diabetes. This brief review examines the role of inflammation in the development of atherosclerosis. Furthermore, it outlines the utility of inflammatory markers and, in particular, adhesion molecules as biomarkers for cardiovascular risk and the factors that affect their level in the circulation. It then discusses the relationship between sleep and markers of inflammation and the role of sleep in immune function.

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References

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    1. Miller MA, Cappuccio FP. Cellular adhesion molecules and their relationship with measures of obesity and metabolic syndrome in a multiethnic population. Int J Obes (Lond) 2006;30:1176–82. - PubMed
    1. Cappuccio FP, Taggart FM, Kandala NB, et al. Meta-analysis of short sleep duration and obesity in children and adults. Sleep. 2008;31:619–26. - PMC - PubMed
    1. Cappuccio FP, D’Elia L, Strazzullo P, Miller MA. Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep. 2010;33:585–92. - PMC - PubMed
    1. Cappuccio FP, D’Elia L, Strazzullo P, Miller MA. Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. Eur Heart J. 2011;32:1484–92. - PubMed

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