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Review
. 2011 Oct 15;7(5 Suppl):S9-11.
doi: 10.5664/JCSM.1342.

Biomarkers and heart disease

Michelle A Albert  1
Affiliations
Review

Biomarkers and heart disease

Michelle A Albert. J Clin Sleep Med. .

Abstract

This review will focus on the evaluation of biomarkers and surrogate endpoints in chronic disease risk with a focus on cardiovascular disease. It provides an example of how identification of relevant biomarkers might be useful in sleep research and clinical care. Much of this review is derived from work performed by the Institute of Medicine (IOM) Committee on Qualification of Biomarkers and Surrogate Endpoints in Chronic Disease (see footnote in the Acknowledgments). This discussion will review the committee charge, definitions of biomarkers and other endpoints, biomarker evaluation framework, case studies of representative biomarkers, recommendations, and conclusions.

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References

    1. Institute of Medicine Committee on Qualification of Biomarkers and Surrogate Endpoints in Chronic Disease. Washington, DC: The National Academies Press; 2010. Report on the Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease. - PubMed
    1. The Cardiac Arrhythmia Suppression Trial (CAST) Investigators. Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. N Engl J Med. 1989;321:406–12. - PubMed
    1. Ridker PM, Danielson E, Fonseca FA, et al. JUPITER Study Group. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008;359:2195–207. - PubMed

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