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. 2011;2(3):247-56.
Epub 2011 Jul 20.

Regulation and function of the TAZ transcription co-activator

Chenying Liu, Wei Huang, Qunying Lei

Regulation and function of the TAZ transcription co-activator

Chenying Liu et al. Int J Biochem Mol Biol. 2011.

Abstract

TAZ (WWTR1), identified as a 14-3-3 binding protein with a PDZ binding motif, is implicated in mesenchymal stem cell differentiation. TAZ has been shown to be negatively regulated by phosphorylation-dependent and phosphorylation-independent mechanisms. Coupled with ASPP2, PP1 dephosphorylates TAZ to activate TAZ. TEADs mediate TAZ function in promoting cell proliferation and epithelial-mesenchymal transition (EMT). TAZ senses different cellular signals such as cell density and the extracellular matrix stiffness. Significantly, TAZ is overexpressed in breast cancer samples and papillary thyroid carcinoma tissues. These results indicate that TAZ plays an important role in cancer development and presents a novel target for TAZ overexpressed cancer therapy.

Keywords: 14-3-3 binding protein; PDZ binding motif; TAZ (WWTR1); epithelial-mesenchymal transition (EMT); signal transduction; stem cell.

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Figures

Figure 1.
Figure 1.
TAZ structure domain. TAZ contains WW domain, a 14-3-3 binding motif, a coiled-coiled motif in the transactivation domain and a PDZ-binding motif in the C-terminal. TB: Tead Binding Domain; TA: Transcriptional Activation Domain.
Figure 2.
Figure 2.
TAZ is regulated by LATS and PP1. TAZ is negatively and positively regulated by LATS kinase and PP1 phosphatase, respectively.
See this image and copyright information in PMC

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