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Review
. 1990 Jun;3(6 Pt 2):82S-86S.

Dopamine and natriuresis. Mechanism of action and developmental aspects

I Seri  1
Affiliations
  • PMID: 2200437
Review

Dopamine and natriuresis. Mechanism of action and developmental aspects

I Seri. Am J Hypertens. 1990 Jun.

Abstract

The present paper summarizes our studies on the mechanisms of the dopamine induced changes in renal macro- and microcirculation as well as in proximal and distal tubular sodium handling which contributes to the natriuresis induced by the drug. Some aspects of the physiological role of locally generated dopamine in regulating sodium excretion are also reviewed. Finally, by describing the cardiovascular, renal and hormonal effects of dopamine in the preterm human neonate, some of the developmental aspects of the renal effects of the drug are also discussed.

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